391 GENTAMICIN THERAPY IN PREMATURE NEONATES: DOSAGE INTERVAL (DI) BASED ON GESTATIONAL AGE (GA)
نویسندگان
چکیده
منابع مشابه
Gentamicin dosage intervals in neonates: longer dosage interval--less toxicity.
OBJECTIVES The aim of this study was to determine the incidence of toxic trough serum gentamicin levels in neonates in the first week of life, with different dosage intervals. METHODS This was a retrospective study of neonates born between 01.07.95 and 31.12.95, who received gentamicin. Data were collected on birth weight, gestation, gentamicin dose, the trough level of gentamicin, serum crea...
متن کاملGentamicin dosage in preterm and term neonates.
Pre-dose and peak serum levels of gentamicin were measured in 82 neonates (25-42 weeks' gestational age), and for comparison in 10 infants and 9 children. Dosage was 2-2.5 mg/kg twice daily for the neonates, and three times daily for infants and children. Neonates were subdivided according to gestational age and weight. Serum levels of gentamicin were very variable in all groups. Preterm neonat...
متن کاملPharmacokinetic basis for the use of extended interval dosage regimens of gentamicin in neonates.
OBJECTIVES To analyse the pharmacokinetic basis for the use of extended-interval dosage regimens of gentamicin in neonates using population pharmacokinetics. PATIENTS AND METHODS The population pharmacokinetics of gentamicin was studied retrospectively in a population of 113 neonates divided into two groups: one for computing the population model (n=97) and another for validation (n=36). A on...
متن کاملGentamicin dosage in children.
The results of 49 serum gentamicin assays from children of 2 weeks to 11 years of age are presented. The dose of gentamicin given 8-hourly intramuscularly ranged from 0-7 mg/kg-4-9 mg/kg. Doses of 1-7 mg/kg or less did not give adequate serum concentrations. As a result of these observations it is suggested that an intramuscular dose of 2-5 mg/kg given 8-hourly is suitable for most children in ...
متن کاملGentamicin therapy in preterms: a comparison of two dosage regimens.
OBJECTIVE To compare the pharmacokinetic profile of gentamicin given as a once daily dose as against the conventional twelve hourly dose in preterm neonates. DESIGN Randomized double blind study. SETTING Tertiary level Neonatal Intensive Care Unit. SUBJECTS Eighteen preterms admitted during the period January 1994 to May 1994. METHODS The babies were randomly assigned to receive either ...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1985
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198504000-00421